ESRF-banner
The Ewing’s Sarcoma Research Foundation (ESRF) is a non-profit organization focused helping teens survive cancer. Ewing’s Sarcoma is an aggressive form of bone cancer that affects teens. Childhood cancers are the second leading cause of death in children under 18 and yet there is a shocking lack of research. ESRF is focused on creating a community of support for these teens, raising awareness, and finding the cure by funding cutting-edge research.

What is Ewing’s Sarcoma?

Ewing’s Sarcoma is a rare malignant round-cell tumor most commonly found in the bone and soft tissue. It was discovered by James Ewing (1866-1943) and was previously mistaken for lymphoma.

Where are the tumors usually found?

The tumor may arise anywhere in the body, usually in the long bones of the arms and legs, the pelvis, or the chest. It may also develop in the skull or the flat bones of the trunk. The tumor often spreads to the lungs and other bones. Metastasis at the time of diagnosis is present in approximately one-third of children with Ewing’s sarcoma. Rarely, Ewing’s sarcoma can occur in adults.

More Info

The cause of this cancer has not been found but This cancer is not inherited and is not caused by the environment. Oncologists do not know. Ewing’s sarcoma can occur any time during childhood and young adulthood, but usually develops during puberty, when bones are growing rapidly.



There are few symptoms. The most common is pain and occasionally swelling at the site of the tumor. Children may also break a bone at the site of the tumor after a seemingly minor injury (this is called a “pathologic fracture”). Fever may also be present.
The outlook depends on the location of the tumor, and whether or not the cancer has spread. Information provided on this page is cited from Medlineplus.com, which is government sponsored information.
If a tumor is suspected, tests to locate the primary tumor and any spread (metastasis) often include:

• Biopsy

• Bone scan

• Chest x-ray

• CT scan

• MRI

• X-ray

Treatment includes multidrug chemotherapy as well as local disease control with surgery or radiation control. Treatment can also consist of limb salvage or amputation. Treatment length depends on the prognosis. Most patients undergo chemotherapy on a three-week cycle for 6-12 months and radiation therapy for 5-8 weeks. It includes a combination of:

• Chemotherapy

• Cisplatin

• Doxorubicin

• Etoposide

• Ifosfamide

• Methotrexate

• Radiation therapy to the tumor site

• Surgical excision (removal) of tumor